Vyvanse: Now approved for adults with ADHD.

C 6 W hen m y A D H D sym p to m s are

co n tro lled ,

I can focus and

finish what I start."

In a clinical study of adults with ADHD,

once daily Vyvanse significantly improved

symptoms of inattention (eg, lack of focus),

hyperactivity, and impulsivity within one week.

If you have A D H D and have troub le

fo cu sin g , a sk yo u r doctor ab o u t V yva n se .

1-8 6 6 -6 3 0 -12 8 3 , w w w .vyvanse.com

:.:Vy VanSeC

IMPORTANT SAFETY INFORMATION

Vyvanse is indicated for the treatment of ADHD. Efficacy based on two

controlled trials in children aged 6 to 12 and one controlled trial in adults.

Tell the doctor about any heart conditions, including structural

abnorm alities, that you, your child, or a fam ily m em ber, m ay have.

Inform the doctor

immediately

if you or your child develops symptoms

that suggest heart problems, such as chest pain or fainting.

Vyvanse should not be taken if you or your child has advanced disease

of the blood vessels (arteriosclerosis); symptomatic heart disease;

moderate to severe high blood pressure; overactive thyroid gland

(hyperthyroidism); known allergy or unusual reactions to drugs called

sympathomimetic amines (for example, pseudoephedrine); seizures;

glaucoma; a history of problems with alcohol or drugs; agitated states;

taken a monoamine oxidase inhibitor (MAOI) within the last

14

days.

Tell the doctor

before

taking Vyvanse if you or your child is being

treated for or has symptoms of depression (sadness, worthlessness, or

hopelessness) or bipolar disorder; has abnormal thought or visions, hears

abnormal sounds, or has been diagnosed with psychosis; has had seizures

or abnormal EEGs; has or has had high blood pressure; exhibits aggressive

behavior or hostility. Tell the doctor

immediately

if you or your child

develops any of these conditions or symptoms while taking Vyvanse.

Abuse of am phetam ines m ay lead to dependence. M isuse of

am phetam ine m ay cause sudden death and serious cardiovascular

adverse events. These events have also been reported rarely with

am phetam ine use.

Vyvanse was generally well tolerated in clinical studies. The most

common side effects reported in studies of Vyvanse were:

children

-

decreased appetite, difficulty falling asleep, stomachache, and irritability;

adult

- decreased appetite, difficulty falling asleep, and dry mouth.

Aggression, new abnormal thoughts/behaviors, mania, growth

suppression,worsening of motion or verbal tics,and Tourette's syndrome

have been associated with use of drugs of this type. Tell the doctor if

you or your child has blurred vision while taking Vyvanse.

Please see Patient Brief Sum m ary of Full Prescribing Inform ation

on the follow ing page.

cShire.-your ADHD Support Company™

€<2009

Shire US lnc.VYV

00210

01/09

You are encouraged to report negative side effects of prescription drugs to the FDA. V isit www.fda.gov/m edwatch, or call 1-80 0 -FD A -10 88.